Mitochondrial Protein Sorting
نویسندگان
چکیده
منابع مشابه
Protein sorting: Recognizing mitochondrial presequences
The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting 'presequence' provides exciting insight into the molecular mechanism of signal recognition.
متن کاملResponse: The Mitochondrial β-Signal and Protein Sorting
to differences in targeting signals in their N-terminal regions, which are completely different. This analysis is not comprehensive. Some unknown proteins that were annotated as not having a mitochondrial localization may have been missed, and there may be classes of MBOMPs without β-signals or that, like Mmm2, have β-signals distal from the C terminus. Nevertheless the process we describe find...
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How are proteins sorted to different destinations in eukaryotic cells? Until recently, it was generally thought that the constitutive flow of proteins to the cell surface occurs by default, and that proteins simply accumulate carbohydrate modifications as they pass sequentially through each compartment along the secretory pathway [1]. This hypothesis was supported by studies showing that inhibi...
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Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino-terminal presequences, but instead contain different types of internal targeting signals. Recent studies have revealed an unexpected complexity of the mitochondrial protein import machinery and have led to the disc...
متن کاملSorting pathways of mitochondrial inner membrane proteins.
Two distinct pathways of sorting and assembly of nuclear-encoded mitochondrial inner membrane proteins are described. In the first pathway, precursor proteins that carry amino-terminal targeting signals are initially translocated via contact sites between both mitochondrial membranes into the mitochondrial matrix. They become proteolytically processed, interact with the 60-kDa heat-shock protei...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m602679200